Article
Homozygous deletions of p16/MTS1 and p15/MTS2 genes are frequent in t(1;19)-negative but not in t(1;19)-positive B precursor acute lymphoblastic leukemia in childhood.
Leukemia - 1 Jul 1996
Ohnishi H, Hanada R, Horibe K, Hongo T, Kawamura M, Naritaka S, Bessho F, Yanagisawa M, Nobori T, Yamamori S, Hayashi Y
Abstract excerpt
We analyzed 60 B precursor acute lymphoblastic leukemia (ALL) primary samples and 15 cell lines for homozygous deletions of p16 and p15 genes and mutations of p16 gene. These included five cell lines and 13 primary samples with the t(1;19)(q23;pl3), and eight primary samples with the t(9;22)(q34;...
Topics
- Base Sequence
- Blotting, Southern
- Carrier Proteins
- Cell Cycle Proteins
- Child
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 19
- Cyclin-Dependent Kinase Inhibitor p15
- Cyclin-Dependent Kinase Inhibitor p16
- Gene Deletion
- Genes, Tumor Suppressor
- Homozygote
- Humans