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Article

Mutations of c-kit JM domain are found in a minority of human gastrointestinal stromal tumors.

Oncogene - 11 Mar 1999

Moskaluk C A, Tian Q, Marshall C R, Rumpel C A, Franquemont D W, Frierson H F

Abstract excerpt

The c-kit gene encodes a transmembrane receptor kinase (KIT) which is expressed in the majority of human gastrointestinal stromal tumors (GISTs), a subtype of gastrointestinal mesenchymal neoplasms. A previous study identified mutations in the juxtamembrane (JM) domain of c-kit in five of six GISTs (Science 279: 577, 1998). To better define the frequency and spectrum of c-kit gene mutations in mesenchymal...

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Identifiers

PMID: 10086344
DOI: 10.1038/sj.onc.1202496

Genes

KIT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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