Article
Gastrointestinal stromal tumors with internal tandem duplications in 3' end of KIT juxtamembrane domain occur predominantly in stomach and generally seem to have a favorable course.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2003
Lasota Jerzy, Dansonka-Mieszkowska Agnieszka, Stachura Tomasz, Schneider-Stock Regine, Kallajoki Markku, Steigen Sonja E, Sarlomo-Rikala Maarit, Boltze Carsten, Kordek Radzislaw, Roessner Albert, Stachura Jerzy, Miettinen Markku
Abstract excerpt
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. GISTs express KIT and have KIT mutations. Majority of these mutations cluster in the 5' end of the KIT juxtamembrane domain. Little is known about the clinicopathological profile of GIST carrying internal tandem duplications in the 3' end of KIT juxtamembrane domain (ITDs in the 3' KIT-JM). In this study,...
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