Article
Immunohistochemical profile and c-kit mutations in gastrointestinal stromal tumors.
Pathology, research and practice - 1 Jan 2005
Romagnoli Solange, Graziani Daniela, Bramerio Manuela, Gambacorta Marcello, Colombo Piergiuseppe, Roncalli Massimo, Coggi Guido, Bosari Silvano
Abstract excerpt
Gastrointestinal stromal tumors (GISTs) are low-grade sarcomas arising from the interstitial cells of Cajal, harboring mutation of c-kit. We investigated the morphological, immunohistochemical, and molecular profile of 55 GISTs to establish the prevalence of mutations, their clinical significance, and diagnostic utility. c-kit mutations were investigated by evaluating the entire coding sequence of the gene with...
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