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Biology of Gastrointestinal Stromal Tumors: <i>KIT</i> Mutations and Beyond

1 Jan 2004

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the digestive tract. Aspects of the morphology and immunophenotype in GISTs resemble those in the interstitial cells of Cajal (ICC), which are a specialized cell type responsible for coordinating peristaltic activity throughout the gastrointestinal tract. Therefore, it is possible that GISTs result from transformation of...

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PMID: 15069768
DOI: 10.1081/cnv-120027585

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