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Article

Bioinformatic analysis of KIT juxtamembrane domain mutations in Syrian GIST patients: jigsaw puzzle completed.

Journal of the Egyptian National Cancer Institute - 14 Aug 2023

Pharaon Nour, Habbal Wafa, Monem Fawza

Abstract excerpt

BACKGROUND: The huge number of detected somatic KIT mutations highlights the necessity of in silico analyses that are almost absent in the relevant medical literature. The aim of this study is to report the mutation spectrum analysis of exon 11 encoding the juxtamembrane (JM) domain of the KIT gene in a group of Syrian GIST patients. METHODS: Forty-eight formalin-fixed paraffin-embedded GIST tissue samples,...

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Identifiers

PMID: 37574490
DOI: 10.1186/s43046-023-00185-0
PMCID: PMC13313953

Genes

KIT

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