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Article

c-kit mutations in gastrointestinal stromal tumors occur preferentially in the spindle rather than in the epithelioid cell variant.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2002

Wardelmann Eva, Neidt Iris, Bierhoff Erhard, Speidel Nicola, Manegold Christoph, Fischer Hans-Peter, Pfeifer Ulrich, Pietsch Torsten

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) coexpress CD34 and the Kit tyrosine-kinase receptor (CD117). A subset of GISTs carry gain-of-function mutations of the c-kit proto-oncogene in its juxtamembrane domain. The relationship between the mutational status and histological as well as immunohistochemical features has not been assessed in detail. 36 GISTs and 14 other gastrointestinal mesenchymal tumors were...

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Share to Antigens, CD34
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrointestinal Neoplasms

Share to Polymorphism, Single-Stranded Conformational

Share to Proto-Oncogene Mas

Share to Proto-Oncogene Proteins c-bcl-2

Share to Proto-Oncogene Proteins c-kit

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Source

Identifiers

PMID: 11850541
DOI: 10.1038/modpathol.3880504

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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