Transformation is associated with an increase in sensitivity to TNF-mediated lysis as a result of an increase in TNF-induced protein tyrosine phosphatase activity.

Abstract excerpt

Using the tumor necrosis factor (TNF)-resistant cell line B/CN and an anchorage-independent variant, 10ME, we have shown a relationship between transformation and sensitivity to TNF. Here, we report a role for protein tyrosine phosphorylation in expression of these phenotypes. Several studies have demonstrated the involvement of protein phosphorylation in the TNF signaling pathways that leads to cell death. We...

Topics

• Animals
• Cell Line
• Cell Transformation, Neoplastic
• Drug Resistance, Neoplasm
• Enzyme Activation
• Enzyme Induction
• Enzyme Inhibitors
• Humans
• Mice
• Mice, Inbred BALB C
• Mice, Nude