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Article

Hamster pancreatic beta cell lines with altered sensitivity towards apoptotic signalling by phosphatase inhibitors.

British journal of pharmacology - 1 Feb 2000

Krautheim A, Brechlin P, Becker K, Winkler M, Steinfelder H J

Abstract excerpt

Specific inhibitors of serine/threonine phosphatases like okadaic acid can induce apoptotic cell death in the pancreatic beta cell line HIT. Cultivation in stepwise increased concentrations of okadaic acid enabled the isolation of HIT100R cells which proliferate at 100 nM okadaic acid (8 - 10 times the initially lethal concentration). These two cell lines were used to characterize the events triggered by okadaic...

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Identifiers

PMID: 10683193
DOI: 10.1038/sj.bjp.0703113
PMCID: PMC1571898

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