Article
Establishment of okadaic acid resistant cell clones using a cDNA expression library.
Cell death and differentiation - 1 Jul 2001
Sandal T, Ahlgren R, Lillehaug J, Døskeland S O
Abstract excerpt
The mechanism whereby the universal apoptogen and serine/threonine phosphatase inhibitor okadaic acid (OA) kills cells, is still unclear. To create a novel tool for probing of OA action, fibroblasts were selected for OA-resistance after infection with a retroviral Jurkat T-cell cDNA expression library. Twenty-one clones were selected. Two of these (OAR1, OAR2) were studied in detail. OAR1 and 2 had each a...
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