Tumor necrosis factor mediated cytolysis requires the adenovirus E1a protein but not the transformed phenotype.

doi:10.1016/0168-1702(90)90030-f

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Article

Tumor necrosis factor mediated cytolysis requires the adenovirus E1a protein but not the transformed phenotype.

Virus research - 1 Mar 1990

Rodrigues M, Dion P, Sircar S, Weber J M

Abstract excerpt

Adenovirus transformed cells are susceptible to lysis by human recombinant tumor necrosis factor (TNF). This susceptibility correlates with the presence of E1a in these cells. A flat revertant cell line which expresses a biologically functional E1a but not the transformed phenotype was neverthele...

Topics

Adenoviridae
Adenovirus Early Proteins
Animals
Cell Line
Cell Transformation, Viral
Cytotoxicity, Immunologic
Oncogene Proteins, Viral
Phenotype
Transcription, Genetic
Tumor Necrosis Factor-alpha

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