TPA induction of EL4 resistance to macrophage-released TNF: role of ADP-ribosylation in tumoricidal activities of TNF and other factors.

doi:10.1016/0008-8749(90)90116-9

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Article

TPA induction of EL4 resistance to macrophage-released TNF: role of ADP-ribosylation in tumoricidal activities of TNF and other factors.

Cellular immunology - 15 Apr 1990

Fishman M, Essani N, Costlow M

Abstract excerpt

Activated macrophages synthesize and release numerous tumoricidal soluble factors that can be divided into receptor- or nonreceptor-dependent agents. Tumor necrosis factor (TNF) would be an example of the former. In our experimental model the killing of EL4 thymoma cells by syngeneic activated macrophages involves, but not exclusively, TNF. Our results show that approximately 50% of the anti-EL4 activity...

Topics

Animals
Antibodies
Benzamides
Calcimycin
Cytotoxicity, Immunologic
Cytotoxins
Down-Regulation
Genetic Variation
Macrophage Activation
Mice
Niacinamide
Pertussis Toxin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Poly(ADP-ribose) Polymerase Inhibitors

Recombinant Proteins

Tetradecanoylphorbol Acetate

Thymoma

Thymus Neoplasms

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 2138520
DOI: 10.1016/0008-8749(90)90116-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2138520-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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