Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selection of hprt mutant T cells as surrogates for dividing cells reveals a restricted T cell receptor BV repertoire in insulin-dependent diabetes mellitus.

Clinical immunology (Orlando, Fla.) - 1 Mar 1999

Falta M T, Magin G K, Allegretta M, Steinman L, Atkinson M A, Brostoff S W, Albertini R J

Abstract excerpt

T cells with somatically acquired mutations in the hypoxanthine-guanine phosphoribosyltransferase (hprt) gene were isolated from patients with insulin-dependent diabetes mellitus (IDDM) as representatives of populations potentially enriched for in vivo activated T cells. TCRB gene V region usage among mutant isolates from individual IDDM patients, but not from normal controls, showed a pronounced preference for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cloning, Molecular

Share to Diabetes Mellitus, Type 1

Share to Gene Rearrangement, beta-Chain T-Cell Antigen Receptor

Share to Hypoxanthine Phosphoribosyltransferase

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to T-Lymphocyte Subsets

Source

Identifiers

PMID: 10075863
DOI: 10.1006/clim.1998.4664

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selection of hprt mutant T cells as surrogates for dividing cells reveals a restricted T cell receptor BV repertoire in insulin-dependent diabetes mellitus.PMID 10075863Read ↗

Spectratyping analysis of the islet-reactive T cell repertoire in diabetic NOD Igμ(null) mice after polyclonal B cell reconstitution.Semantic proximity Read ↗

Different TCRBV genes generate biased patterns of V-D-J diversity in human T cells.Semantic proximity Read ↗

Influence of antigenic experience on BJ gene segment usage in human CD4+ T cells.Semantic proximity Read ↗

Myelin basic protein peptide specificity and T-cell receptor gene usage of HPRT mutant T-cell clones in patients with multiple sclerosis.Semantic proximity Read ↗

Determination of hprt mutant and mutation frequencies and the molecular characterization of human derived in vivo T-lymphocyte mutants.Semantic proximity Read ↗

Retrovirus-Mediated Gene Transfer in Primary T Lymphocytes: Influence of the Transduction/Selection Process and of <i>ex Vivo</i> Expansion on the T Cell Receptor β Chain Hypervariable Region RepertoireSemantic proximity Read ↗

TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line.Semantic proximity Read ↗

Molecular characterization of hypoxanthine guanine phosphoribosyltransferase mutant T cells in human blood: The concept of surrogate selection for immunologically relevant cells.Semantic proximity Read ↗

Altered VH6-D-JH repertoire in human insulin-dependent diabetes mellitus and autoimmune idiopathic thrombocytopenic purpura.Semantic proximity Read ↗

HPRT mutations, TCR gene rearrangements, and HTLV-1 integration sites define in vivo T-cell clonal lineages.Semantic proximity Read ↗

Hypoxanthine-guanine phosphoribosyltransferase reporter gene mutation for analysis of in vivo clonal amplification in patients with HTLV type 1-associated Myelopathy/Tropical spastic paraparesis.Semantic proximity Read ↗

Azathioprine associated T-cell mutations in insulin-dependent diabetes mellitus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.