Article
HPRT mutations, TCR gene rearrangements, and HTLV-1 integration sites define in vivo T-cell clonal lineages.
Environmental and molecular mutagenesis - 1 Jan 2000
Allegretta Mark, Ardell Stephanie K, Sullivan Linda M, Jacobson Steven, Mortreux Franck, Wattel Eric, Albertini Richard J
Abstract excerpt
HPRT mutations in vivo in human T-lymphocytes are useful probes for mechanistic investigations. Molecular analyses of isolated mutants reveal their underlying mutational changes as well as the T-cell receptor (TCR) gene rearrangements present in the cells in question. The latter provide temporal reference points for other perturbations in the in vivo clones as well as evidence of clonal relationships among mutant...
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