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Repair of Large Insertion/Deletion Heterologies in Human Nuclear Extracts Is Directed by a 5′ Single-strand Break and Is Independent of the Mismatch Repair System

1 Mar 1999

Abstract excerpt

The repair of 12-, 27-, 62-, and 216-nucleotide unpaired insertion/deletion heterologies has been demonstrated in nuclear extracts of human cells. When present in covalently closed circular heteroduplexes or heteroduplexes containing a single-strand break 3' to the heterology, such structures are subject to a low level repair reaction that occurs with little strand bias. However, the presence of a single-strand...

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PMID: 10066813
DOI: 10.1074/jbc.274.11.7474

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