Article
Nick-directed repair of palindromic loop mismatches in human cell extracts.
Journal of biomedical science - 1 Jan 2005
Chuang Yi-Kuang, Cheng Wern-Cherng, Goodman Steven D, Chang Yu-Ting, Kao Jau-Tsuen, Lee Chun-Nan, Tsai Keh-Sung, Fang Woei-horng
Abstract excerpt
Palindromic sequences present in DNA may form secondary structures that block DNA replication and transcription causing adverse effects on genome stability. It has been suggested that hairpin structures containing mispaired bases could stimulate the repair systems in human cells. In this study, processing of variable length of palindromic loops in the presence or absence of single-base mismatches was investigated...
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