Nick-directed repair of palindromic loop mismatches in human cell extracts.

doi:10.1007/s11373-005-7891-y

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Article

Nick-directed repair of palindromic loop mismatches in human cell extracts.

Journal of biomedical science - 1 Jan 2005

Chuang Yi-Kuang, Cheng Wern-Cherng, Goodman Steven D, Chang Yu-Ting, Kao Jau-Tsuen, Lee Chun-Nan, Tsai Keh-Sung, Fang Woei-horng

Abstract excerpt

Palindromic sequences present in DNA may form secondary structures that block DNA replication and transcription causing adverse effects on genome stability. It has been suggested that hairpin structures containing mispaired bases could stimulate the repair systems in human cells. In this study, processing of variable length of palindromic loops in the presence or absence of single-base mismatches was investigated...

Topics

Bacteriophages
Base Pair Mismatch
Base Sequence
Catalysis
DNA
DNA Repair
Escherichia coli
HeLa Cells
Humans
Hydrolysis
Magnesium
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Nucleic Acid Heteroduplexes

Source

Open in PubMed

Identifiers

PMID: 16078003
DOI: 10.1007/s11373-005-7891-y

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Transcription, Genetic