Article
A hPMS2 mutant cell line is defective in strand-specific mismatch repair.
The Journal of biological chemistry - 4 Aug 1995
Risinger J I, Umar A, Barrett J C, Kunkel T A
Abstract excerpt
Human cells contain several homologs of the bacterial mutL gene required for mismatch repair, including a gene on chromosome 7 designated hPMS2. We have identified an endometrial carcinoma cell line, HEC-1-A, that has a C-->T mutation in hPMS2 that generates a nonsense codon and yields a protein...
Topics
- Adenosine Triphosphatases
- Base Sequence
- Carcinoma
- Chromosomes, Human, Pair 7
- DNA Repair
- DNA Repair Enzymes
- DNA, Satellite
- DNA-Binding Proteins
- Endometrial Neoplasms
- Female
- Humans
- Methylnitronitrosoguanidine
- Mismatch Repair Endonuclease PMS2
- Molecular Sequence Data
- Mutation
- Neoplasm Proteins
- Repetitive Sequences, Nucleic Acid
- Tumor Cells, Cultured