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Differential human nucleotide excision repair of paired and mispaired cisplatin-DNA adducts

1 Feb 1997

Abstract excerpt

In order to understand the action of the chemotherapeutic drug cisplatin, it is necessary to determine why some types of cisplatin-DNA intrastrand crosslinks are repaired better than others. Using cell extracts and circular duplex DNA, we compared nucleotide excision repair of uniquely placed 1,2-GG, 1,2-AG, and 1,3-GTG cisplatin-crosslinks, and a 2-acetylaminofluorene lesion. The 1,3 crosslink and the...

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PMID: 9016585
DOI: 10.1093/nar/25.3.480

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Source receipt: pubmed, retrieved 7 Sept 2026.

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