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Article

Bi-directional Processing of DNA Loops by Mismatch Repair-dependent and -independent Pathways in Human Cells

1 Feb 2003

Abstract excerpt

Previous work has shown that small DNA loop heterologies are repaired not only through the mismatch repair (MMR) pathway but also via an MMR-independent pathway in human cells. However, how DNA loop repair is partitioned between these pathways and how the MMR-independent repair is processed are not clear. Using a novel construct that completely and specifically inhibits MMR in HeLa extracts, we demonstrate here...

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PMID: 12458199
DOI: 10.1074/jbc.m210687200

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