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Article

Nucleotide excision repair in human cells: fate of the excised oligonucleotide carrying DNA damage in vivo.

The Journal of biological chemistry - 19 Jul 2013

Hu Jinchuan, Choi Jun-Hyuk, Gaddameedhi Shobhan, Kemp Michael G, Reardon Joyce T, Sancar Aziz

Abstract excerpt

Nucleotide excision repair is the sole mechanism for removing the major UV photoproducts from genomic DNA in human cells. In vitro with human cell-free extract or purified excision repair factors, the damage is removed from naked DNA or nucleosomes in the form of 24- to 32-nucleotide-long oligomers (nominal 30-mer) by dual incisions. Whether the DNA damage is removed from chromatin in vivo in a similar manner and...

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PMID: 23749995
DOI: 10.1074/jbc.M113.482257
PMCID: PMC3774362

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XPC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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