Case-sibling gene-association studies for diseases with variable age at onset.

Abstract excerpt

Studies which compare cases to disease-free siblings are useful for assessing association between a genetic locus and a phenotypic trait, as they eliminate the possibility of confounding by population stratification. Many analytic methods for such family-based studies are based on a binary disease model. However, complex diseases have variable age at onset. Consequently, binary-outcome methods can be inefficient...

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