Article
Loss of immunohistochemical E-cadherin expression in colon cancer is not due to structural gene alterations.
Virchows Archiv : an international journal of pathology - 1 Jun 1999
Schuhmacher C, Becker I, Oswald S, Atkinson M J, Nekarda H, Becker K F, Mueller J, Siewert J R, Höfler H
Abstract excerpt
E-cadherin, a transmembrane cell adhesion molecule, has been observed to have an altered pattern of immunoreactivity in several types of carcinomas. In lobular breast cancer, loss of immunoreactivity has been shown to be due either to out-of-frame deletions or to nonsense mutations of the E-cadherin gene. We analysed 29 cases of completely resected colon carcinoma with immunohistochemistry using the HEC-D1...
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