Mutations of the E-cadherin gene in human gynecologic cancers.

doi:10.1038/ng0594-98

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Article

Mutations of the E-cadherin gene in human gynecologic cancers.

Nature genetics - 1 May 1994

Risinger J I, Berchuck A, Kohler M F, Boyd J

Abstract excerpt

Expression of the E-cadherin cell adhesion molecule is reduced in several types of human carcinomas, and the protein serves as an invasion suppressor in vitro. To determine if mutations of the E-cadherin gene (on chromosome 16q22) contribute to epithelial tumorigenesis, 135 carcinomas of the endo...

Topics

Alleles
Base Sequence
Cadherins
Carcinoma
Codon
DNA Mutational Analysis
DNA, Complementary
DNA, Neoplasm
Endometrial Neoplasms
Female
Gene Deletion
Gene Expression Regulation, Neoplastic
Humans
Molecular Sequence Data
Neoplasm Proteins
Ovarian Neoplasms
Point Mutation
Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 8075649
DOI: 10.1038/ng0594-98

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8075649-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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