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Article

Mutations of the E-cadherin gene in human gynecologic cancers.

Nature genetics - 1 May 1994

Risinger J I, Berchuck A, Kohler M F, Boyd J

Abstract excerpt

Expression of the E-cadherin cell adhesion molecule is reduced in several types of human carcinomas, and the protein serves as an invasion suppressor in vitro. To determine if mutations of the E-cadherin gene (on chromosome 16q22) contribute to epithelial tumorigenesis, 135 carcinomas of the endometrium and ovary were examined for alterations in the E-cadherin coding region. Four mutations were identified: one...

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Identifiers

PMID: 8075649
DOI: 10.1038/ng0594-98

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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