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Article

Mutations in beta-catenin are uncommon in colorectal cancer occurring in occasional replication error-positive tumors.

Cancer research - 15 Oct 1997

Kitaeva M N, Grogan L, Williams J P, Dimond E, Nakahara K, Hausner P, DeNobile J W, Soballe P W, Kirsch I R

Abstract excerpt

Beta-catenin has been identified as an oncogene in colon cancer and melanoma. Phosphorylation of sites in exon 3 of beta-catenin leads to degradation of this protein. These sites are primary targets for activating mutations. The frequency with which oncogenic mutations at these sites are found in colorectal cancer is unknown, as is the frequency of their occurrence in other malignancies. We analyzed 92 colorectal...

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PMID: 9377556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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