Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells.

Journal of cell science - 15 Apr 2010

Roger Lauréline, Jullien Laurent, Gire Véronique, Roux Pierre

Abstract excerpt

Mutations in the p53 tumour suppressor gene are associated clinically with tumour progression and metastasis. Downregulation of the E-cadherin cell-cell adhesion molecule is a key event for epithelial to mesenchymal transition (EMT) in tumour progression. Here, we show that wild-type p53 induced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colonic Neoplasms
Share to Cyclin-Dependent Kinase Inhibitor p21
Share to Drug Combinations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelium

Share to Laminin

Share to Mesoderm

Share to Proteoglycans

Share to Vimentin

Source

Identifiers

PMID: 20332115
DOI: 10.1242/jcs.061002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-20332115-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells.PMID 20332115Read ↗

Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration.Semantic proximity Read ↗

The role of the E-cadherin/catenin complex in gastrointestinal cancer.Semantic proximity Read ↗

p53 and its mutants in tumor cell migration and invasionSemantic proximity Read ↗

Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells.Semantic proximity Read ↗

Identification of GRO1 as a critical determinant for mutant p53 gain of function.Semantic proximity Read ↗

DN-R175H p53 mutation is more effective than p53 interference in inducing epithelial disorganization and activation of proliferation signals in human carcinoma cells: role of E-cadherin.Semantic proximity Read ↗

Tumor Suppressor p53 and Its Homologue p73α Affect Cell MigrationSemantic proximity Read ↗

CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status.Semantic proximity Read ↗

L1-Mediated Colon Cancer Cell Metastasis Does Not Require Changes in EMT and Cancer Stem Cell MarkersSemantic proximity Read ↗

Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: implications of p53 mutation or isoform expression on breast cancer cell invasion.Semantic proximity Read ↗

Target disruption of the mutant beta-catenin gene in colon cancer cell line HCT116: preservation of its malignant phenotype.Semantic proximity Read ↗

p21WAF1 regulates anchorage-independent growth of HCT116 colon carcinoma cells via E-cadherin expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.