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Article

Biallelic mutations of the Tsc2 gene in chemically induced rat renal cell carcinoma.

International journal of cancer - 11 Sept 1998

Satake N, Urakami S, Hirayama Y, Izumi K, Hino O

Abstract excerpt

A number of cancer genes have been identified by the study of hereditary human cancers and shown to be involved in sporadic genesis of the same tumors. We have identified a germline mutation in the rat homologue of the human tuberous sclerosis (TSC2) predisposing gene in the Eker rat model. In this study, we searched for mutations of the Tsc2 gene in chemically induced non-Eker rat renal cell carcinomas (RCs)....

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Source

Identifiers

PMID: 9714060
DOI: 10.1002/(sici)1097-0215(19980911)77:6<895::aid-ijc16>3.0.co;2-0

Genes

TSC2
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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