Biallelic mutations of the Tsc2 gene in chemically induced rat renal cell carcinoma.

doi:10.1002/(sici)1097-0215(19980911)77:6<895::aid-ijc16>3.0.co;2-0

Back to search

Article

Biallelic mutations of the Tsc2 gene in chemically induced rat renal cell carcinoma.

International journal of cancer - 11 Sept 1998

Satake N, Urakami S, Hirayama Y, Izumi K, Hino O

Abstract excerpt

A number of cancer genes have been identified by the study of hereditary human cancers and shown to be involved in sporadic genesis of the same tumors. We have identified a germline mutation in the rat homologue of the human tuberous sclerosis (TSC2) predisposing gene in the Eker rat model. In th...

Topics

Alleles
Animals
Carcinogens
Carcinoma, Renal Cell
DNA Primers
Diethylnitrosamine
Exons
Kidney Neoplasms
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Rats
Rats, Inbred F344
Tuberous Sclerosis

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.