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Article

Modulation of HERG potassium channels by extracellular magnesium and quinidine.

Journal of cardiovascular pharmacology - 1 Feb 1999

Po S S, Wang D W, Yang I C, Johnson J P, Nie L, Bennett P B

Abstract excerpt

Torsades de pointes is a polymorphic ventricular arrhythmia resulting from congenital or drug-induced (acquired) QT prolongation. Pharmacologic suppression of repolarizing potassium currents is one mechanism causing the acquired long QT (LQT) syndrome. Recent studies have linked mutations in a gene encoding a potassium channel subunit (HERG) to the LQT syndrome. Clinical experience indicates that intravenous...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10028924
DOI: 10.1097/00005344-199902000-00002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of HERG potassium channels by extracellular magnesium and quinidine.PMID 10028924Read ↗

Block of the human ether-a-go-go-related gene (hERG) K+ channel by the antidepressant desipramine.Semantic proximity Read ↗

Blockade of the human ether-a-go-go-related gene potassium channel by ketamine.Semantic proximity Read ↗

Extracellular K+ is a prerequisite for the function and plasma membrane stability of HERG channels.Semantic proximity Read ↗

Atypical tetracyclic antidepressant maprotiline is an antagonist at cardiac hERG potassium channels.Semantic proximity Read ↗

Propofol inhibits hERG K+ channels and enhances the inhibition effects on its mutations in HEK293 cells.Semantic proximity Read ↗

Modulation of Potassium Channels as a Therapeutic ApproachSemantic proximity Read ↗

Lack of negatively charged residues at the external mouth of Kir2.2 channels enable the voltage-dependent block by external Mg2+.Semantic proximity Read ↗

Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652.Semantic proximity Read ↗

Cooperative regulation of Ca(v)1.2 channels by intracellular Mg(2+), the proximal C-terminal EF-hand, and the distal C-terminal domain.Semantic proximity Read ↗

Blockage of hERG current and the disruption of trafficking as induced by roxithromycin.Semantic proximity Read ↗

H(1) antihistamine drug promethazine directly blocks hERG K(+) channel.Semantic proximity Read ↗

Inactivation gating determines drug potency: a common mechanism for drug blockade of HERG channels.Semantic proximity Read ↗

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