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Article

Extracellular K+ is a prerequisite for the function and plasma membrane stability of HERG channels.

Circulation research - 2 Apr 2010

Massaeli Hamid, Guo Jun, Xu Jianmin, Zhang Shetuan

Abstract excerpt

RATIONALE: The human ether-a-go-go-related gene (HERG) encodes the pore-forming subunits of the rapidly activating delayed rectifier potassium channel (I(Kr)) that is important for cardiac repolarization. Dysfunction of HERG causes long QT syndrome (LQTS) which can lead to sudden cardiac death. We previously showed that a reduction in extracellular K(+) concentration ([K(+)](o)) prolongs QT intervals in intact...

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Identifiers

PMID: 20133899
DOI: 10.1161/CIRCRESAHA.109.215970

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Related research

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Research trail→

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Extracellular K+ is a prerequisite for the function and plasma membrane stability of HERG channels.PMID 20133899Read ↗

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A novel missense mutation causing a G487R substitution in the S2-S3 loop of human ether-à-go-go-related gene channel.Semantic proximity Read ↗

Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel.Semantic proximity Read ↗

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HERG, a human inward rectifier in the voltage-gated potassium channel family.Semantic proximity Read ↗

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