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Article

Blockage of hERG current and the disruption of trafficking as induced by roxithromycin.

Canadian journal of physiology and pharmacology - 1 Dec 2013

Han Sheng-Na, Yang Song-Hua, Zhang Yu, Duan Yan-Yan, Sun Xiao-Yan, Chen Qiu, Fan Tian-Li, Ye Zhen-Kun, Huang Chen-Zheng, Hu Xiang-Jie, Zhang Zhao, Zhang Li-Rong

Abstract excerpt

Roxithromycin is an oral macrolide antibiotic agent that has been repeatedly reported to provoke excessive prolongation of the Q-T interval and torsades de pointes in clinical settings. To investigate the mechanisms underlying the arrhythmogenic side effects of roxithromycin, we studied the molecular mechanisms of roxithromycin on human ether-à-go-go-related gene (hERG) K(+) channels expressed in human embryonic...

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Identifiers

PMID: 24289083
DOI: 10.1139/cjpp-2012-0456

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Blockage of hERG current and the disruption of trafficking as induced by roxithromycin.PMID 24289083Read ↗

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