Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stabilization of beta-catenin by genetic defects in melanoma cell lines.

Science (New York, N.Y.) - 21 Mar 1997

Rubinfeld B, Robbins P, El-Gamil M, Albert I, Porfiri E, Polakis P

Abstract excerpt

Signal transduction by beta-catenin involves its posttranslational stabilization and downstream coupling to the Lef and Tcf transcription factors. Abnormally high amounts of beta-catenin were detected in 7 of 26 human melanoma cell lines. Unusual messenger RNA splicing and missense mutations in t...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to DNA-Binding Proteins
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Point Mutation

Share to RNA, Messenger

Share to Transcription Factors

Source

Identifiers

PMID: 9065403
DOI: 10.1126/science.275.5307.1790

Genes

APC
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9065403-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stabilization of beta-catenin by genetic defects in melanoma cell lines.PMID 9065403Read ↗

Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma.Semantic proximity Read ↗

The WNT/Beta-catenin pathway in melanomaSemantic proximity Read ↗

Mutations in exon 3 of the beta-catenin gene are rare in melanoma cell lines.Semantic proximity Read ↗

Genetic and epigenetic alterations of the APC gene in malignant melanoma.Semantic proximity Read ↗

Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC.Semantic proximity Read ↗

Beta-catenin in the melanocyte lineage.Semantic proximity Read ↗

Dysregulation of the Wnt/β-Catenin Signaling Pathway in Canine Cutaneous Melanotic TumorSemantic proximity Read ↗

Loss of membranous expression of beta-catenin is associated with tumor progression in cutaneous melanoma and rarely caused by exon 3 mutations.Semantic proximity Read ↗

Alteration in E-cadherin/β-catenin expression in canine melanotic tumors.Semantic proximity Read ↗

[Nuclear beta-catenin localization is not sufficient for canonical Wnt signaling activation in human meianoma cell lines].Semantic proximity Read ↗

Beta-catenin mutations in cell lines established from human colorectal cancers.Semantic proximity Read ↗

Immune suppression and resistance mediated by constitutive activation of Wnt/β-catenin signaling in human melanoma cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.