Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Nuclear beta-catenin localization is not sufficient for canonical Wnt signaling activation in human meianoma cell lines].

Molekuliarnaia biologiia - 1 Jan 2000

Kulikova K V, Posviatenko A V, Gnuchev N V, Georgiev G P, Kibardin A V, Larin S S

Abstract excerpt

In most cases, advanced stages of melanoma are practically incurable due to high metastatic potential of tumor cells. Multiple observations support the idea that aberrations in Wnt signaling pathway play a significant role in melanoma development and progression. Canonical Wnt signaling activation results in stabilization and accumulation of the major effector molecule called beta-catenin. Mutations promoting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Genes, Reporter

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Luciferases

Share to Melanoma

Share to Organ Specificity

Share to Skin Neoplasms

Share to Wnt Signaling Pathway

Share to Wnt3A Protein

Source

Identifiers

PMID: 22393786

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Nuclear beta-catenin localization is not sufficient for canonical Wnt signaling activation in human meianoma cell lines].PMID 22393786Read ↗

Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma.Semantic proximity Read ↗

The WNT/Beta-catenin pathway in melanomaSemantic proximity Read ↗

Phospho-β-catenin expression in primary and metastatic melanomas and in tumor-free visceral tissues, and associations with expression of PD-L1 and PD-L2.Semantic proximity Read ↗

Loss of membranous expression of beta-catenin is associated with tumor progression in cutaneous melanoma and rarely caused by exon 3 mutations.Semantic proximity Read ↗

Constitutive activation of Wnt/beta-catenin signaling pathway in migration-active melanoma cells: role of LEF-1 in melanoma with increased metastatic potential.Semantic proximity Read ↗

Phospho-β-catenin expression in primary and metastatic melanomas and in tumor-free visceral tissuesSemantic proximity Read ↗

Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma.Semantic proximity Read ↗

The role of Wnt/β-catenin signaling pathway in melanoma epithelial-to-mesenchymal-like switching: evidences from patients-derived cell lines.Semantic proximity Read ↗

Illegitimate WNT pathway activation by beta-catenin mutation or autocrine stimulation in T-cell malignancies.Semantic proximity Read ↗

Stabilization of beta-catenin by genetic defects in melanoma cell lines.Semantic proximity Read ↗

Dysregulation of the Wnt/β-Catenin Signaling Pathway in Canine Cutaneous Melanotic TumorSemantic proximity Read ↗

Frequent beta-catenin overexpression without exon 3 mutation in cutaneous lymphomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.