Article

Phospho-β-catenin expression in primary and metastatic melanomas and in tumor-free visceral tissues

2020-09-13

Abstract excerpt

β-catenin (βcat) is an important downstream effector in the Wnt signaling pathway and plays an important role in the development and progression of many cancers including melanoma. βcat expression is regulated by GSK-3β-mediated phosphorylation at positions 33, 37 and 41. In normal cells, phosphorylation at these sites triggers proteasomal degradation, which in turn prevents accumulation of free cytoplasmic βcat....

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Literature Corpus work: baefc1f1-1072-5632-85c9-89cc504d73d1
DOI: 10.1101/2020.09.13.295410

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