Article
Loss of membranous expression of beta-catenin is associated with tumor progression in cutaneous melanoma and rarely caused by exon 3 mutations.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2002
Demunter Anouk, Libbrecht Louis, Degreef Hugo, De Wolf-Peeters Chris, van den Oord Joost J
Abstract excerpt
beta-Catenin plays a fundamental role in the regulation of the E-cadherin-catenin cell adhesion complex. It also plays a role in the Wnt signaling pathway by activating T-cell factor- and lymphoid enhancer factor-regulated gene transcription. The level of beta-catenin in cells is tightly controlled in a multiprotein complex, and mutations in the glycogen synthase kinase 3beta (GSK-3beta) phosphorylation sites of...
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