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Article

Molecular mechanisms of development of multiple endocrine neoplasia 2 by RET mutations.

Journal of internal medicine - 1 Jun 1998

Takahashi M, Asai N, Iwashita T, Murakami H, Ito S

Abstract excerpt

Biological and biochemical effects of multiple endocrine neoplasia type 2A (MEN-2A), type 2B (MEN-2B) and familial medullary thyroid carcinoma (FMTC) mutations on Ret function were investigated by transfection of NIH 3T3 cells. All mutations examined conferred transforming activity on Ret at variable levels. Cysteine mutations detected in MEN-2A and FMTC induced disulphide-linked homodimers of Ret on the cell...

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Source

Identifiers

PMID: 9681851

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Molecular mechanisms of development of multiple endocrine neoplasia 2 by RET mutations.PMID 9681851Read ↗

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The different RET-activating capability of mutations of cysteine 620 or cysteine 634 correlates with the multiple endocrine neoplasia type 2 disease phenotype.Semantic proximity Read ↗

Multiple endocrine neoplasia type 2 and RET: from neoplasia to neurogenesis.Semantic proximity Read ↗

Biological properties of Ret with cysteine mutations correlate with multiple endocrine neoplasia type 2A, familial medullary thyroid carcinoma, and Hirschsprung's disease phenotype.Semantic proximity Read ↗

Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2.Semantic proximity Read ↗

A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins.Semantic proximity Read ↗

The Multiple Endocrine Neoplasia SyndromesSemantic proximity Read ↗

Molecular implications of RET mutations for pheochromocytoma risk in multiple endocrine neoplasia 2.Semantic proximity Read ↗

Tissue-specific carcinogenesis in transgenic mice expressing the RET proto-oncogene with a multiple endocrine neoplasia type 2A mutation.Semantic proximity Read ↗

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