Molecular mechanisms of development of multiple endocrine neoplasia 2 by RET mutations.

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Article

Molecular mechanisms of development of multiple endocrine neoplasia 2 by RET mutations.

Journal of internal medicine - 1 Jun 1998

Takahashi M, Asai N, Iwashita T, Murakami H, Ito S

Abstract excerpt

Biological and biochemical effects of multiple endocrine neoplasia type 2A (MEN-2A), type 2B (MEN-2B) and familial medullary thyroid carcinoma (FMTC) mutations on Ret function were investigated by transfection of NIH 3T3 cells. All mutations examined conferred transforming activity on Ret at vari...

Topics

Carcinoma, Medullary
Drosophila Proteins
Hirschsprung Disease
Humans
Multiple Endocrine Neoplasia Type 2a
Multiple Endocrine Neoplasia Type 2b
Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-ret
Receptor Protein-Tyrosine Kinases
Thyroid Neoplasms
Tyrosine

Source

Open in PubMed

Identifiers

PMID: 9681851

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9681851-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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