Article
Genomic Profiling of Cancerous Areas, Dysplasia, and Background Mucosa in Ulcerative Colitis-associated Colorectal Cancer.
Anticancer research - 1 Jun 2026
Funakoshi Kaoruko, Sasaki Kazuhito, Hata Keisuke, Nozawa Hiroaki, Murono Koji, Emoto Shigenobu, Yokoyama Yuichiro, Shinagawa Takahide, Kohsaka Shinji, Shinozaki-Ushiku Aya, Ushiku Tetsuo, Oda Katsutoshi, Tatsuno Kenji, Miyagawa Kiyoshi, Aburatani Hiroyuki, Mano Hiroyuki, Ishihara Soichiro
Abstract excerpt
BACKGROUND/AIM: Ulcerative colitis (UC) is associated with an increased risk of colorectal cancer (CRC), and unlike sporadic CRC, colitis-associated CRC (CAC) develops through a dysplasia-carcinoma sequence rather than the traditional adenoma-carcinoma pathway. However, studies that have simultaneously analyzed background mucosa, dysplasia, and carcinoma within the same patient remain limited. This study aimed to...
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