High resolution genetic typing of the class II HLA-DRB1 locus using group-specific amplification and SSO-hybridisation in microplates.

doi:10.1111/j.1601-5223.1998.00161.x

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Article

High resolution genetic typing of the class II HLA-DRB1 locus using group-specific amplification and SSO-hybridisation in microplates.

Hereditas - 1 Jan 1998

Allen M, Eriksson I, Liu L, Gyllensten U

Abstract excerpt

The HLA-DRB1 locus is one of the most polymorphic HLA class II loci and rapid and accurate typing of this polymorphism is important both in bone-marrow transplantation, analysis of disease association and in forensic medicine. The allelic variation at DRB1 is characterized by combinations of a limited number of amino-acid motifs, reducing the resolution of a typing strategy based on a single PCR and subsequent...

Topics

Alleles
Base Sequence
DNA Primers
HLA-DR Antigens
HLA-DRB1 Chains
Histocompatibility Testing
Humans
Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 10022082
DOI: 10.1111/j.1601-5223.1998.00161.x

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