Article
Full screening and accurate subtyping of HLA-A*02 alleles through group-specific amplification and mono-allelic sequencing.
Cellular & molecular immunology - 1 Nov 2013
Song Shengli, Han Miaomiao, Zhang Han, Wang Yuanxia, Jiang Hong
Abstract excerpt
HLA-A*02 is the most prevalent and polymorphic major histocompatibility complex (MHC) allele family in humans. Functional differences have been revealed among subtypes, demanding further subtyping of HLA-A*02 in basic and clinical settings. However, the fast growing polymorphisms render traditional primer- or probe-based typing methods impractical and result in increasing ambiguities in direct sequence-based...
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