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Ursodeoxycholic acid (UDCA) mitigates the host inflammatory response during <i>Clostridioides difficile</i> infection by altering gut bile acids which attenuates NF-κB signaling via bile acid activated receptors

2020-01-21

Abstract excerpt

Clostridioides difficile infection (CDI) is associated with increasing morbidity and mortality posing an urgent threat to public health. Recurrence of CDI after successful treatment with antibiotics is high, thus necessitating discovery of novel therapeutics against this enteric pathogen. Administration of the secondary bile acid ursodeoxycholic acid (UDCA, ursodiol) inhibits the life cycle of various strains of...

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Literature Corpus work
fff66b8a-e878-5190-98e9-678ccfdf7d00
DOI
10.1101/2020.01.16.910018
Open publication

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Ursodeoxycholic acid (UDCA) mitigates the host inflammatory response during <i>Clostridioides difficile</i> infection by altering gut bile acids which attenuates NF-κB signaling via bile acid activated receptorsDOI 10.1101/2020.01.16.910018
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