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<i>Clostridioides difficile</i> Toxins Alter Host Metabolic Pathway and Bile Acid Homeostasis Gene Expression In Colonic Epithelium

2025-03-21

Abstract excerpt

A major risk factor for acquiring Clostridioides difficile is antibiotic usage that disrupts a healthy microbial gut community facilitating establishment of infection. Once established, C. difficile secretes endotoxins (TcdA and TcdB) that are internalized into host colonic epithelial cells where they disrupt gut barrier function and induce hyper inflammation resulting in severe diarrhea and possibly leading to...

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Literature Corpus work
95d088df-958c-5bf5-9d83-ed5058b578c3
DOI
10.1101/2025.03.21.644594
Open publication

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<i>Clostridioides difficile</i> Toxins Alter Host Metabolic Pathway and Bile Acid Homeostasis Gene Expression In Colonic EpitheliumDOI 10.1101/2025.03.21.644594
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