Article

The role of bile-metabolising enzymes in the pathogenesis of Clostridioides difficile infection, and the impact of faecal microbiota transplantation

2019-01-01

Abstract excerpt

The pathogenesis of Clostridioides difficile infection (CDI), and mechanisms of efficacy of faecal microbiota transplant (FMT) in treating recurrent CDI (rCDI), remain poorly-understood. Certain bile acids affect the ability of C. difficile to undergo germination or vegetative growth. Loss of gut microbiota-derived bile-metabolising enzymes may predispose to CDI via perturbation of bile metabolism, and restitution...

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Literature Corpus work: a52be7b4-c626-5705-a0c5-c91d776b25b2
DOI: 10.25560/73899

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