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A New Hypothesis for <em>Clostridioides difficile</em> Infection Vulnerability: Epithelial Damage and Inflammatory Repair May Prime the Host for Infection

2026-06-26

Abstract excerpt

Clostridioides difficile can persist within the colon across a spectrum ranging from colonization to severe infection (CDI). Although progression to CDI is strongly associated with antibiotic exposure and colonic inflammation, current models do not fully explain why hosts with similar risk factors can differ in their vulnerability to CDI. Here, it is hypothesized that epithelial damage, inflammation, and regenerat...

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Identifiers and source

Literature Corpus work
49f597d0-3fb5-55c7-98df-5fa41c0a0733
DOI
10.20944/preprints202606.2004.v1
Open publication

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