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UPC2 mutations and development of azole resistance in Candida albicans hospital isolates from Lebanon.

Journal of global antimicrobial resistance - 1 Sept 2024

Fattouh Nour, Hdayed Dana, Hijazi Ahmad, Tokajian Sima, Khalaf Roy A

Abstract excerpt

OBJECTIVES: This study evaluated the role of Upc2 in the development of azole resistance in Candida albicans isolates from Lebanese hospitalized patients and determined a correlation between resistance and virulence. METHODS: The UPC2 gene which codes for an ergosterol biosynthesis regulator was sequenced and analysed in two azole-resistant and one azole-susceptible C. albicans isolates. An amino acid...

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Antifungal Agents
Azoles
Candida albicans
Candidiasis
Chitin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Drug Resistance, Fungal

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PMID: 39059553
DOI: 10.1016/j.jgar.2024.07.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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