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Article

IL-1R8 acts as an immune checkpoint in CD8⁺ T Cells

2020-01-01

Abstract excerpt

IL-1R8 is a member of the Interleukin-1 receptor (ILR) family, acting as a negative regulatory receptor that inhibits inflammation by dampening ILR and Toll-like receptor (TLR) signaling pathways. IL-1R8 deficiency was shown to enhance IL-18-promoted NK cell effector functions restraining tumor metastasis and viral dissemination. IL-1R8 is thus considered a new immunocheckpoint of innate lymphoid cells. CD8⁺ T cel...

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Literature Corpus work
ffea2bf5-6a7b-53c2-b79e-59b8385b8f0f
DOI
10.21954/ou.ro.00011fff
Open publication

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IL-1R8 acts as an immune checkpoint in CD8⁺ T CellsDOI 10.21954/ou.ro.00011fff
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