Article

Hydroxychloroquine as Adjuvant Therapy with Immunotherapy for Prevention of Activation of Latent Tuberculosis: Restoring Interferon-Gamma Competence in Patients Receiving TNF-Alpha Inhibitors

2026-03-17

Abstract excerpt

<h4>Background: </h4> Tumor necrosis factor-alpha (TNF-α) inhibitors have transformed the management of chronic inflammatory diseases, yet they impose a substantially elevated risk of tuberculosis (TB) reactivation—up to 25-fold depending on the agent used. This risk is principally driven by disruption of granuloma architecture and suppression of interferon-gamma (IFN-γ)–dependent macrophage bactericidal activity....

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Literature Corpus work: ffe8af7e-ba14-59e7-b150-7a2cdc3d0c7f
DOI: 10.20944/preprints202603.1220.v1

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Hydroxychloroquine as Adjuvant Therapy with Immunotherapy for Prevention of Activation of Latent Tuberculosis: Restoring Interferon-Gamma Competence in Patients Receiving TNF-Alpha InhibitorsDOI 10.20944/preprints202603.1220.v1Read

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