Article

NR4A1 limits CD8 <sup>+</sup> T Cell effector responses and protection in tuberculosis

2026-01-13

Abstract excerpt

During Mycobacterium tuberculosis ( Mtb ) infection, CD8 + T cells exhibit dysfunction with impaired cytotoxicity and limited localization to granuloma cores. Using knockout mice, adoptive-transfer models and validation in macaque and human datasets, we identified the nuclear receptor NR4A1 as a key restrainer of CD8 + T cell immunity in tuberculosis (TB). Mtb -infected Nr4a1 -/- mice displayed reduced bacte...

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Literature Corpus work: 1ce7daf5-1525-5642-9b4d-874f0de1a7dd
DOI: 10.64898/2026.01.12.699051

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