Article

NR4A1 limits CD8⁺ T Cell effector responses and protection in tuberculosis

2026-01-13

Abstract excerpt

<title>Abstract</title> <p>During Mycobacterium tuberculosis (Mtb) infection, CD8⁺ T cells exhibit dysfunction with impaired cytotoxicity and limited localization to granuloma cores. Using knockout mice, adoptive-transfer models and validation in macaque and human datasets, we identified the nuclear receptor NR4A1 as a key restrainer of CD8+ T cell immunity in tuberculosis (TB). Mtb-infected Nr4a1-/- mice display...

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Literature Corpus work: c0b55ed0-aeae-5c82-8e77-8e95baed04d8
DOI: 10.21203/rs.3.rs-8363336/v1

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