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MDSC depletion during immunization with heat-killed <i>Mycobacterium tuberculosis</i> increases protection against BCG infection

2025-02-05

Abstract excerpt

Tuberculosis (TB) is still one of the deadliest infectious diseases globally. Although i.d. BCG immunization offers limited protection, a vaccine based on Mycobacterium tuberculosis (Mtb) has yet to be approved. Our previous findings demonstrated that s.c. immunization with heat-killed Mtb significantly increased the number of monocytic myeloid-derived suppressor cells (M-MDSC) in mice. Therefore, we hypothesized...

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Literature Corpus work
5c93b40b-d3ee-5a13-b3fc-5c615b2d8d52
DOI
10.1101/2025.01.31.635639
Open publication

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MDSC depletion during immunization with heat-killed <i>Mycobacterium tuberculosis</i> increases protection against BCG infectionDOI 10.1101/2025.01.31.635639
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