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Long noncoding RNA <i>HSCHARME</i> is altered in human cardiomyopathies and promotes stem cell-derived cardiomyocyte differentiation by splicing regulation

2024-11-06

Abstract excerpt

<h4>ABSTRACT</h4> A growing body of evidence suggests that tissue-specific long noncoding RNAs (lncRNA) play pivotal roles in the heart. Here, we exploited the synteny between the mouse and human genomes to identify the novel lncRNA HSCHARME ( H uman S yntenic CHARME ) and combined single-cell transcriptomics, CAGE-seq data, RNA-FISH imaging and CRISPR-Cas9 genome editing to document its role in cardiomyogene...

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Literature Corpus work
ffce9a9e-bb14-5583-ab55-41bb249b90b9
DOI
10.1101/2024.11.06.622297
Open publication

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Long noncoding RNA <i>HSCHARME</i> is altered in human cardiomyopathies and promotes stem cell-derived cardiomyocyte differentiation by splicing regulationDOI 10.1101/2024.11.06.622297
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