Article

Integrated cell atlas and tumoroids chart pancreatic cancer therapeutic targets

2025-10-06

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is characterized by dense, fibroblast-rich stroma that actively shapes the tumor microenvironment. Most PDAC cases arise from conserved genetic transformations initiated by oncogenic KRAS mutations, developing into metastatic disease with high mortality rates. To chart universal PDAC cell states and identify therapeutic inroads, we integrated published single-cell transcript...

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Literature Corpus work: ffb2c3c6-dcfb-5602-b76d-4ea9d68f7727
DOI: 10.1101/2025.09.30.679518

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