Article

Pancreatic adenocarcinoma human organoids share structural and genetic features with primary tumors

2018-06-04

Abstract excerpt

<h4>ABSTRACT</h4> Patient-derived pancreatic ductal adenocarcinoma (PDAC) organoid systems show great promise for understanding the biological underpinnings of disease and advancing therapeutic precision medicine. Despite the increased use of organoids, the fidelity of molecular features, genetic heterogeneity, and drug response to the tumor of origin remain important unanswered questions limiting their utility....

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Literature Corpus work: 306d0a7a-dabf-57c4-91a6-5cbf01f0eece
DOI: 10.1101/338897

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